#2525 THE 2021 CKD EPI GLOMERULAR FILTRATION RATE ESTIMATING EQUATION AND RISK OF HOSPITALIZATION FOR KIDNEY DISEASE

Abstract Background and Aims The revised Chronic Kidney Disease Epidemiology Collaboration (CKD EPI) equation for estimated glomerular filtration rate (eGFR) reduced CKD prevalence among Asians, but few studies have evaluated its impact on healthcare utilization. We aimed to evaluate the of 2009-eGFRcr(ASR) [1] 2021-eGFRcr(AS) [2] equations risk hospitalization kidney disease multi-ethnic Asians. Method Retrospective cohort study adults who consulted at Singapore's largest cluster public institutions had a baseline serum creatinine performed in 2014. eGFR was calculated using both eGFRcr(ASR) categorized as G1 (≥90 ml/min/1.73 m2), G2 (60-89 mL/min/1.73 G3A (45-59 G3B (30-44 G4 (15-29 G5 (<15 m2). Electronic medical records were used identify demographic clinical information, outcome including acute injury, chronic disease, dialysis or transplant next three years until December 2017. Multi-variable logistic regression models compare disease. Model discrimination assessed area (AUC) under receiver operating characteristic (ROC) curve. Results Among 33007 Asian included study, median age 69.0 (interquartile range 63.0, 76.0). majority Chinese (79.5%; Indian 7.2%, Malay 10.2% other race 3.2%), female (53.3%), diabetes (56.4%) received statin therapy (71.6%) baseline. Hospitalization occurred 1915 (7.1% 26874 individuals) after excluding those with missing covariates (n = 5133). incidence increased worsening function (Table 1) regardless estimation used. After adjusting age, sex, ethnicity, comorbidities (cardiovascular diabetes, hypertension, cancer, systolic diastolic blood pressure, body mass index) medications (statin, ACE inhibitor, angiotensin receptor blocker, loop thiazide diuretic), categories independently associated 2). Compared G1, risks G2, G3A, incremental approximately 2, 6, 10 20 times, respectively, while 100 times that G1. AUCs 0.859 (95% CI: 0.849-0.869) model eGFRcr (ASR) 0.861 0.852-0.871) 2021-eGFRcr (AS) difference not significant (p 0.11). Conclusion Lower eGFRs ascertained by 2009 greater did significantly alter discrimination.